APP and atherosclerosis: Strikingly, 10 genes exhibited shared dysregulation in both aging and atherosclerosis, including Vcam1, Apoe, Gdf15, Timp1, Cxcl12, Hspd1, Serpine1, App, Eln, and Hif1a (Figure 3D), suggesting their potentially critical roles in the atherosclerosis driven by aging in HGPS mice.