Produced more indole-3-lactic acid, which enhanced H3K27ac binding at the enhancer regions of IL-12a, thereby boosting IL-12a production in dendritic cells and priming CD8+ T cell immunity against tumor growth.Indole-3-lactic acid transcriptionally inhibited Saa3 expression, altering cholesterol metabolism of CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.