Specifically, MPO and CCL3 are associated with “cytokine-cytokine receptor interaction,” while TLR8 is enriched in the “Toll-like receptor signaling pathway.” These results are in accordance with existing studies that emphasize the roles of chemokines and cytokines in shaping the immunological microenvironment and influencing disease progression in AML (16, 22). Here, MPO is linked to acute myeloid leukemia.