In addition, knockdown of NDUFA4L2 in HCC cells has been shown to suppress tumor growth and metastasis (30), which is consistent with our findings of elevated NDUFA4L2, OLFML2B, SEMA5B, and RASL12 expression in HCC tissues and their significant negative correlation with patient survival. The gene discussed is SEMA5B; the disease is hepatocellular carcinoma.