Beyond its established efficacy in acute promyelocytic leukemia and neuroblastoma, ATRA exhibits multifaceted antitumor effects, such as reprogramming pancreatic stellate cells to inhibit desmoplasia and invasion (88), suppressing colorectal carcinogenesis via miR-3666 (89), and reversing tamoxifen resistance in breast cancer through Pin1 targeting (90). This evidence concerns the gene PIN1 and breast cancer.