GPT and Hyperbilirubinemia: However, indicators of hepatic dysfunction were both more prevalent and severe: any-grade hypoalbuminemia occurred in 59.1% of patients, hyperbilirubinemia in 38.7%, while Grade 3/4 transaminase elevations(ALT 12.9%, AST 16.2%) and hyperbilirubinemia(10.8%) also represented substantial proportions.