CD8A and cancer: Emerging evidence confirms B cells’ multifaceted roles in cancer immunity, including cytokine-mediated enhancement of CD8+ T cell cytotoxicity, granzyme B secretion for direct tumor lysis, and antibody-dependent cellular phagocytosis (46),Following epitope selection, molecular docking simulations validated robust binding affinities between prioritized epitopes and their cognate HLA alleles (Supplementary Table S2).