TNF and neoplasm: They can directly kill tumor cells through (a) cytokine-mediated cytotoxicity (e.g. TNFα and IFNγ), (b) perforin (PFN) & granzyme (GzmB) and FasL & TRAILR mediated target cell apoptosis, (c) antibody-dependent cell-mediated cytotoxicity, and (d) antigen processing and presentation.