RUNX3 and Sepsis: The elevated proportion of sepsis Th17 cells in this dataset compared to bacteraemia samples displayed downregulation of genes involved in cell differentiation (RUNX3; -0.45log2FC), NF-κB signalling (LTB, BIRC3, LGALS1, and CD74; -1.0, -0.75, -0.56, and -0.36log2FC, respectively) and activation pathways (Figures 5C, 6E).