PIK3IP1 and Sepsis: Transcriptional analysis highlighted the downregulation of NF-κB signalling (LGALS1 and BIRC3; -1.07 and -0.78log2FC, respectively), activation (CCL5; -2.20log2FC)., and cell adhesion processes (Figures 5B, 6C, Supplementary Table S8) On the other hand, immune regulatory genes BTG1 (0.46log2FC), PIK3IP1 (0.44log2FC), T cell activation markers CD27 (0.86log2FC), FYB (0.67log2FC), and TRAT1 (0.56log2FC) were upregulated in sepsis CM CD4+ T cells (Figure 5B, 6D, Supplementary Table S8) (49–51).