Downregulated genes in sepsis Th2 cells were significantly overrepresented in processes related to viral responses (including TNFRSF25 and GIMAP5; -0.79 and -0.49log2FC, respectively) and differentiation (ZAP70; -0.66log2FC) (Figures 3D, 4G). The gene discussed is GIMAP5; the disease is Sepsis.