Conversely the upregulated genes in sepsis Th1 cells showed enhanced endopeptidase activity (GAPDH; 0.75log2FC) and angiogenesis related (XBP1, CXCR4, and BTG1; 0.93, 0.66, and 0.64log2FC, respectively) pathways (Figure 4F). This evidence concerns the gene XBP1 and Sepsis.