In macrophages, saturated fatty acids (SFAs) engage the IRE1α pathway to promote the activation of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, which in turn leads to the secretion of IL-1β, a pro-inflammatory cytokine closely linked to insulin resistance (37). This evidence concerns the gene NLRP3 and Insulin resistance.