BMAL1 and tuberculosis: Several pieces of evidence in the literature have suggested an interplay between circadian rhythm and TB: i) among the symptoms, cough is more frequent during daytime together with higher sputum bacillary load (74); ii) the metalloproteinase production by Mtb-infected cells has been shown to depend on Bmal1, the central gene in the circadian loop (75–77); and iii) it has been shown that BCG efficacy is influenced by the time of immunization (78).