Although evidence-based cutoffs remain sparse [10], our institutional thresholds for VWD, hemophilia A, and hemophilia B were similar to those recently endorsed by the International Society on Thrombosis and Haemostasis (ISTH) Delphi consensus, but were slightly less conservative for FVII and FXIII deficiencies [17]. The gene discussed is VWF; the disease is hemophilia B.