It has been reported that ILA improves colorectal tumors by regulating the epigenetic mechanism of anti-tumor infiltration of CD8+T cells 30, while supplementing with I3P can restore the growth of liver cancer cells lacking Trp, indicating that I3P is an important tumor metabolite in MYC driven liver tumors 31. This evidence concerns the gene TNFRSF9 and colorectal neoplasm.