Paradoxically, both BALB/c mice (a high-anxiety model) and anxiety patients with 22q11.2 deletion syndrome exhibit elevated CD4+/CD8+ ratios27, suggesting that helper T cells, primarily functioning through cytokine secretion, play a critical role in emotional regulation, with outcomes influenced by cytokine secretion biases. The gene discussed is CD4; the disease is 22q11.2 deletion syndrome.