To further investigate the role of DDB2 in mediating chemoresistance, we analyzed the correlation between DDB2 gene expression and sensitivity to chemotherapeutic agents in BRCA, LUAD, LUSC, LIHC, and CHOL cell lines (Genomics of Drug Sensitivity in Cancer) 35 using three independent datasets: the Cancer Cell Line Encyclopedia (CCLE) 36, GDSC 37, and Klijn et al. 38 (Figure 2A). The gene discussed is DDB2; the disease is cancer.