Through its roles in NER and HR, DDB2 promotes DNA repair following genotoxic stress, enabling cancer cells to survive treatment with DNA-damaging agents such as doxorubicin 17, platinum compounds 45, PARP inhibitors 16, or radiotherapy 46 in breast, colorectal, and pancreatic cancers, respectively. Here, DDB2 is linked to familial pancreatic carcinoma.