Echocardiographic analysis indicated that fibroblasts-specific knockout of IGFBP6 increased EF and FS in mice subjected to MI surgery, but the protective effects of IGFBP6 knockout in CFs were abolished when MFAP4 was overexpressed (Figure 10B-E, Supplementary material online Table S8). Here, IGFBP6 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.