Furthermore, FBXW7 suppresses EMT and chemoresistance in NSCLC by degrading ZEB2, while FBXW7 deletion promotes EMT by enhancing the stabilization of ZEB2, thereby promoting oxaliplatin and 5-fluorouracil (5-FU) resistance in CRC in vitro, ex vivo, and in vivo132. This evidence concerns the gene FBXW7 and non-small cell lung carcinoma.