Furthermore, FBXW7 ubiquitinates and degrades Notch1 to suppress Notch signaling-induced EMT 209, while E3 ligase MIB1 and TRIM67 promote EMT and cell invasion in NSCLC by positively regulating the Notch signaling 210, 211. The gene discussed is FBXW7; the disease is non-small cell lung carcinoma.