SNAI1 and cancer: Similarly, USP9X enhances Snail stability by removing K48-linked ubiquitin chains, contributing to cisplatin and doxorubicin (Dox) resistance in TNBC in vitro and in vivo102, while TGF-β-induced USP27X stabilizes Snail and activates cancer-associated fibroblasts, reducing cisplatin sensitivity in TNBC in vitro and in vivo109.