CRBN and acute myeloid leukemia: For instance, CC-90009 recruits the cullin4-RING E3 ubiquitin ligase (CRL4)-cereblon (CRBN) complex to induce proteasomal degradation of G1-to-S phase transition 1 (GSPT1), leading to potent suppression of acute myeloid leukemia (AML) in preclinical studies 318.