In addition, STK32C depletion suppressed tumor sizes and volumes of HCT116 cells in BALB/c nude mice with decreased expression of STK32C, proliferating cell nuclear antigen (PCNA) as a proliferation marker, HSP90, p-AKT1 with no toxicity by Immunohistochemistry, suggesting antitumor effect of STK32C depletion in vivo via inhibition of HSP90 and AKT signaling axis. The gene discussed is AKT1; the disease is neoplasm.