As that tumor metastasis modulated differentiation of T cells by Asn secretion required proximity to the cognate T cell, we analyzed the distance from tumor metastasis (ova+) to TTSM (CD8+CD44+CD62L+TCF+) in TdLNs and found that the distance from overexpressed ASNSWT group was shorter than other two groups (Figure 6K). This evidence concerns the gene HNF4A and neoplasm.