In alignment with results on metastatic TdLNs in mouse models, among the CD8+ T cells, the proportion of activated T cells (CD8+CD45RO+), Tsl (CD8+CD45RO+TCF-1+) cells, and TTSM (CD8+CD45RO+CD62L+ TCF-1+) cells were significantly elevated in the vicinity of tumor metastases in TdLNs of lung cancer patients from ASNS-high-group in contrast to that from ASNS-low-group (Figure 6P-U). The gene discussed is CD8A; the disease is lung cancer.