CD8A and neoplasm: To further investigate whether TTSM cells were similarly enriched in metastatic TdLNs and the impact of ASNS on the process, we demonstrated that lung cancer cells with high ASNS expression enhanced CD8+T cells activation, memory, as well as generation of Tsl and TTSM cells in metastatic TdLNs, and sequentially promoted infiltration of CD8+T cells in primary tumor sites to control tumor growth.