Moreover, the Tsl subset in TdLNs has been characterized as TdLN-derived stem-like and memory T cells (CD44+CD62L+TCF1+Tox-, TTSM), which have been shown to act as primary responders to immune checkpoint blockade (ICB) treatment in preclinical models and lung cancer patients 16-18. Here, TCF7 is linked to lung carcinoma.