On the other hand, Mettl14 decreases m6A modification of Nova2 mRNA, enabling Ythdf2-mediated degradation and inhibit Nova2 activity140, Conditional knockout of Mettl3, decreases m6A modification of Lats2 mRNA, thereby inhibiting the nuclear entry of Yap, downregulates profibrotic genes and causing HSCs to switch from an activated state to a quiescent state141, blocking HF progression. This evidence concerns the gene NOVA2 and hydrops fetalis.