METTL14 and hepatocellular carcinoma: Mettl14-induced m6A modification stabilizes Usp48 and Sirt6, suppressing HCC glycolysis and malignancy160, reduces circORC5 expression to inhibit gastric cancer, and enhances circSTX6 in HCC161, while possibly downregulating Hnf3γ (which is negatively correlated with malignancy/survival) via m6A modification, with exogenous Hnf3γ promoting liver cancer cell differentiation and growth inhibition162.