Alkbh5-mediated demethylation of Foxo1 mRNA enhances its stability, upregulating superoxide dismutase (Sod2) to lower Ros levels, thereby maintaining cancer stem cell traitsand conferring chemoresistance in triple-negative breast cancer; Alkbh5 depletion sensitizes cells to doxorubicin by decreasing Foxo1/Sod2 expression95. The gene discussed is ALKBH5; the disease is cancer.