Mettl16 promotes NAFLD via m6A mediated cell death inducing DFFA-like effector A (Cidea) upregulation129, whereas Rbm15 reduces NAFLD by m6A-methylating ring finger protein 5 (Rnf5) to ubiquitinate and degrade Rock1130. Here, RNF5 is linked to metabolic dysfunction-associated steatotic liver disease.