STAT3 and neoplasm: Mettl3 mediates Socs2 degradation, modulates Snail's epithelial-mesenchymal transition, and promotes cell proliferation/lipid production via modifying Rdm1 and stabilizing Linc00958155, 156, forming a positive feedback loop with Stat3 by suppressing anti-tumor CD8+T cells through the Scap-cholesterol axis157, promoting Stat3 mRNA translation, and accelerating metastasis as Stat3 upregulates Wtap to enhance Mettl3's nuclear function158.