It is worth mentioning that Fto emerges as a critical regulator in age-related ALI, where its reduced expression enhances m6A modification of Acsl4 (acyl-CoA synthetase long-chain family member 4) and Tfrc (transferrin receptor 1), promoting ferroptosis and exacerbating lipid peroxidation and Ros accumulation. The gene discussed is ACSL4; the disease is age.