On the one hand, the fungal biological clock precisely regulates toxin synthesis (such as the rhythmic expression of the OTA polyketide synthase gene) and the circadian rhythm of host infection (such as Fusarium oxysporum coordinating the virulence sequence through the transcription factors FoZafA/FoCzf1) (Lu et al., 2025; Schmidt-Heydt et al., 2010). Here, CLOCK is linked to infection.