Further supporting our results, other studies have identified additional molecular mechanisms underlying the antidepressant effects of H2S in models of diabetes and inflammation, including the reduction of ferroptosis and neuroinflammation (Wang et al., 2021), and inhibition of the NF-κB/NLRP3 inflammasome and pyroptosis, along with the preservation of mitochondrial function in the hippocampus (Bao et al., 2023). The gene discussed is NLRP3; the disease is diabetes mellitus.