Type R vessels represent a capillary subtype characterized by high expression of Emcn and Cav1 but lacking Flt4 expression, predominantly localized around trabeculae in adult murine bone, with their abundance increasing in aged mice and positively correlating with improved bone quality, suggesting potential therapeutic relevance for osteoporosis treatment (Mohanakrishnan et al., 2024). Here, CAV1 is linked to osteoporosis.