The Sod enzyme activity in the serum and brain tissue of mice in the control group was 1.70 ± 25.43 and 1.69 ± 0.21 units/ml, respectively, while this level was significantly reduced in the PD group (4.25 ± 11.29 in serum and 0.35 ± 0.76 in brain tissue; P = 0.029 in tissue and P < 0.001 in serum), indicating a severe increase in oxidative stress caused by disease induction. The gene discussed is SOD1; the disease is Parkinson disease.