The findings of this research suggest that NAC and SMC compounds play an effective role in boosting antioxidant defense mechanisms and attenuating lipid peroxidation in Parkinson's by activating the Nrf2/Ho-1 signaling pathway and increasing the expression and activity of antioxidant enzymes, including Sod, Gpx, and Cat. The increase in Nrf2 and Ho-1 levels in the brain, along with the decrease in oxidative stress indicators such as MDA and the increase in TAC, reflects the upregulation of cellular protective responses against oxidative damage. This evidence concerns the gene NFE2L2 and Parkinson disease.