However, the level of 22 cytokines (IL‐17, CCL1, CCL11, CCL2/MCP‐1, CXCL10, CXCL13, IL‐10, IL‐1β, IL‐1rα, IL‐7, IL‐23, IL‐27, CCL12/MCP‐5, M‐CSF, CXCL9/MIG, CCL3/MIP‐1α, CCL4/MIP‐1β, CXCL2/MIP‐2, CCL5/RANTES, CXCL12/SDF‐1, CCL17/TARC and TNF‐α) in both spleen and bone marrow was lower in AML group, suggesting the imbalanced profile of cytokines in AML microenvironment in mice. The gene discussed is IL17A; the disease is acute myeloid leukemia.