However, the level of 22 cytokines (IL‐17, CCL1, CCL11, CCL2/MCP‐1, CXCL10, CXCL13, IL‐10, IL‐1β, IL‐1rα, IL‐7, IL‐23, IL‐27, CCL12/MCP‐5, M‐CSF, CXCL9/MIG, CCL3/MIP‐1α, CCL4/MIP‐1β, CXCL2/MIP‐2, CCL5/RANTES, CXCL12/SDF‐1, CCL17/TARC and TNF‐α) in both spleen and bone marrow was lower in AML group, suggesting the imbalanced profile of cytokines in AML microenvironment in mice. Here, CXCL2 is linked to acute myeloid leukemia.