Resveratrol, a natural activator of SIRT1, has been confirmed by numerous studies to exert multiple neuroprotective effects in Alzheimer's disease models through targeting SIRT1, including antioxidant, anti‐inflammatory, and mitochondrial protective actions, as well as interference with Aβ formation [80, 81]. Here, SIRT1 is linked to early-onset autosomal dominant Alzheimer disease.