In 2014, When the researchers examined the process of changes in the plasma levels of ANXA1 and cortisol in patients with sepsis, they found that there was a subgroup of sepsis patients who were not affected by peripheral blood cortisol levels that had significantly increased plasma levels of ANXA1 [34], suggesting that ANXA1 may be a potential target for diagnosis and treatment of sepsis. This evidence concerns the gene ANXA1 and Sepsis.