Given the known involvement of podosomes in adhesion and matrix remodelling (Alonso et al., 2019), and the reported transcriptional upregulation of MYO1F in neuroinflammatory states associated with neurodegenerative disease (Matarin et al., 2015; Zhang et al., 2013), the conserved podosomal recruitment of MYO1F and its adaptor protein ASAP1 supports a role for this complex in cytoskeletal remodelling and immune function within the central nervous system. Here, MYO1F is linked to neurodegenerative disease.