PPIF and pancreatitis: The impact on necrotic cell death of Pz compounds withthe greatestaffinity for CypD was examined following taurolithocholic acid 3-sulfate(TLCS, 500 μM) exposure of freshly isolated murine pancreaticacinar cells (PACs), an initial site of injury in pancreatitis. Informed by our prior data, we selected 18b, c, and d to evaluate theireffects and compared them with CsA in a concentration-dependent manner(Figure ).