Furthermore, curcumin has the capacity to activate multiple signaling pathways, such as adenosine 5'-monophosphate-activated protein kinase (AMPK) and nuclear factor-kappa B (NF-κB), while suppressing oxidative stress and cell apoptosis (Li et al. 2024); thereby, it alleviates the lipid metabolism disorders associated with non-alcoholic fatty liver disease (NAFLD) (Safari et al. 2023). This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.