By contrast, cancer suppression in LC/CC/BC, METTL1 depletion compromises pri‐miRNA maturation (the let‐7 and miR‐149‐3p programmes) and decreased METTL1 disrupts translation of GADD45A and RB1, ultimately resulting in cancer progression, whereas METTL1 re‐expression restores the phenotype, indicating that the direction of effect is context‐locked to the operative RNA regulon.9, 66, 74. The gene discussed is RB1; the disease is cancer.