In HCC, oncogenic transcriptional states, exemplified by MYC‐driven WDR4 upregulation, favour tRNA‐m7G‐dependent, codon‐biased translation of cell‐cycle and survival mRNAs, thereby amplifying PI3K/AKT and MAPK signalling and promoting proliferation, metastasis and drug resistance. This evidence concerns the gene AKT1 and hepatocellular carcinoma.