In HCC, oncogenic transcriptional states, exemplified by MYC‐driven WDR4 upregulation, favour tRNA‐m7G‐dependent, codon‐biased translation of cell‐cycle and survival mRNAs, thereby amplifying PI3K/AKT and MAPK signalling and promoting proliferation, metastasis and drug resistance. The gene discussed is WDR4; the disease is hepatocellular carcinoma.