Our study proposes that LEF1 is a key gene which is upregulated in AAA and LEF1's association with T‐cell infiltration, but the function of LEF1 has not been demonstrated, and further in vitro and in vivo experiments are needed to explore the function of LEF1 in regulating T cells and thereby affecting aortic aneurysms. The gene discussed is LEF1; the disease is aortic aneurysm.