ProKinO, an ontology tool for searching cancer kinome databases, has also identified various cancer-associated C-spine mutations, such as a valine to phenylalanine substitution in the receptor tyrosine kinase ErbB4 (V732F) and in the serine/threonine kinase BRAF (V471F) in lung carcinoma (93). This evidence concerns the gene NTRK1 and cancer.