A similar pattern was observed for NfL in ALS, with HRs declining from 3.62 (95% CI, 3.23–4.04) at 2 years to 2.08 (95% CI, 1.91–2.27) at 5 years and 1.37 (95% CI, 1.23–1.54) at 10 years. This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.