SLC7A7 and Other metabolic disease: Dysfunctional mutations in Slc7a7 gene lead to lysinuric protein intolerance, a rare metabolic disorder that results from defective transport of cationic amino acids.58 The Slc7a7 knockout mouse model recapitulates this phenotype.59 However, despite these findings, the understanding of Slc7a7's role in macrophages is still limited.