A recent study from the Carotid Artery Risk for Atherosclerosis Study reported an association between elevated sTREM2 levels and carotid plaque progression.55 To further investigate the underlying mechanisms and assess tissue-level expression of TREM2 in advanced human atherosclerosis, we evaluated its association with plaque burden in patients undergoing surgery for high-grade carotid stenosis and CAD. Here, TREM2 is linked to atherosclerosis.