In MD cells, MR activation increased nitric oxide (NO) production and reduced Na+-K+-2Cl- cotransporter membrane expression, both of which were mitigated by MRA or neuronal nitric oxide synthase inhibition.<h4>Conclusion</h4>These findings suggest that esaxerenone restores TGF function via adenosine signalling, attenuating glomerular hyperfiltration and reducing albuminuria. This evidence concerns the gene SLC12A1 and Menkes disease.