PKM and hepatocellular carcinoma: For example, Lu et al. reported that activation of the NF-κB signaling pathway enhances glycolysis in HCC [39], while Xia and colleagues demonstrated that N6-adenosine methyltransferase 5 (METTL5) stabilizes c-Myc protein by promoting USP5 translation, thereby activating downstream glycolytic genes (e.g., ENO1 and PKM2), reprogramming glucose metabolism, and promoting HCC proliferation and metastasis [40].