In a subgroup analysis stratified by gene type, this correlation was significant in HCC patients with PKM (HR = 2.08, 95% CI 1.76–2.46, P < 0.001), SLC2A1 (HR = 1.78, 95% CI 1.22–2.61, P = 0.003), PGK1 (HR = 2.16, 95% CI 1.21–3.83, P = 0.009), ENO1 (HR = 2.09, 95% CI 1.58–2.77, P < 0.001), and ALDOA (HR = 2.21, 95% CI 1.66–2.95, P < 0.001). Here, ALDOA is linked to hepatocellular carcinoma.