PLOD1 and polycystic ovary syndrome: Reproductive symptoms of PCOS are driven by environmental and genetic dysregulation of endocrine processes in tissues of the hypothalamic-pituitary-gonadal (HPG) axis which orchestrates reproductive function through tight temporal control of neuropeptides and hormones, including gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and sex steroids such as estrogen, progesterone, and androgens (23).