In cases such as HNRNPA2 and CHERP, modest and insignificant association with Braak stages and protein levels may indicate interplay between tau deposition and additional disease-associated processes, as well as brain-region specific detection of tau in each tauopathy, i.e., cortical in AD and temporal in PSP and ability to capture insoluble interacting proteins from human tissue IPs. The gene discussed is CHERP; the disease is tauopathy.