Previous work by our group and others has described core spliceosome members, including U1-70K (snRNP70) (22, 33, 122, 126, 127), and disordered RBPs such as G3BP1, TIA1, and SRRM2 in tau aggregation (25, 26, 128), co-aggregating with tau in the cytoplasm across cellular (25), murine models (21, 73) and in human AD brain tissue (22, 23, 122). Here, TIA1 is linked to Alzheimer disease.