MAPT and supranuclear palsy, progressive, 1: In cases such as HNRNPA2 and CHERP, modest and insignificant association with Braak stages and protein levels may indicate interplay between tau deposition and additional disease-associated processes, as well as brain-region specific detection of tau in each tauopathy, i.e., cortical in AD and temporal in PSP and ability to capture insoluble interacting proteins from human tissue IPs.