By integrating additional human brain tau interactome studies and bulk brain proteomics, we show that the TauRD interactome provides shared insight into PPI changes, further reinforcing the role of RBPs in AD and related tauopathies (17, 20, 21, 24, 25, 29, 31, 32, 33, 63, 107, 124, 125). Here, MAPT is linked to Alzheimer disease.