Previous work by our group and others has described core spliceosome members, including U1-70K (snRNP70) (22, 33, 122, 126, 127), and disordered RBPs such as G3BP1, TIA1, and SRRM2 in tau aggregation (25, 26, 128), co-aggregating with tau in the cytoplasm across cellular (25), murine models (21, 73) and in human AD brain tissue (22, 23, 122). This evidence concerns the gene MAPT and Alzheimer disease.