To identify tau interacting or co-aggregating partners, techniques such as affinity purification (AP) using tau antibodies (Abs), along with laser capture microdissection and mass spectrometry (MS), have been employed on postmortem brain tissue from AD cases and revealed numerous pathways and interactors associated with tau, highlighting its roles in translation, energy metabolism, long-term potentiation, and mitochondrial function (13, 14, 15, 16). Here, MAPT is linked to Alzheimer disease.