SKOR2 and Cognitive impairment: Other upregulated genes include Ski family transcriptional corepressor 2 (SKOR2; >3.7-fold), linked to cerebellar Purkinje cells (PCs)44,45; RPL17-C18orf32 (>3.4-fold), a ribosomal protein associated with Alzheimer disease46; and Meis homeobox 2 (MEIS2; >3.2-fold), associated with neuronal dysfunction and intellectual impairment,47,48,49 which were also highly upregulated in LCFs versus RFs (Figure 6I).