In contrast, LCMs exhibited upregulation of genes such as FCγR1-BP, PALB2, DSCC, EPSTI1, CASP5, and MCC associated with immune responses, vascular function, and stress, with a notable downregulation of genes related to immune dysregulation and endothelial dysfunction, highlighting the differences in immune response between the sexes.59 The gene discussed is PALB2; the disease is endothelial dysfunction.