Although absolute counts of terminal effector (TE) T cells in whole blood were not assessed, we found a significant increase in the frequency of TE CD4+ and CD8+ T cell subsets (CD45RA+CCR7+CD95+CD28−)8 in peripheral blood mononuclear cells (PBMCs) from both male and female LC patients compared to R groups (Figures 2F, 2G, and S1A). Here, CD28 is linked to laryngotracheoesophageal cleft.