Pincus-Knackstedt et al35 demonstrated that prenatal stress increases the susceptibility of adult offspring mice to airway inflammation, as evidenced by increased anxiety levels in the adult offspring, reduced expression of corticotropin-releasing hormone in the paraventricular nucleus, and the ability of antigen-presenting cells from prenatally stressed offspring to trigger clonal expansion of Th2 cells in vitro. The gene discussed is CRH; the disease is inflammation.