Interestingly, mutations in molecular chaperones have been found in inherited retinal dysfunction and degeneration [35], HSP90α deficiency causes retinal degeneration [36] and the expression of HSPA5 plays an important role in maintaining the structural integrity of cone photoreceptors and is drastically reduced in donor eyes of atrophic AMD patients [37]. The gene discussed is HSP90AA1; the disease is age-related macular degeneration.