In settings of infection and inflammation, lower AnxA1 levels have been quantified in the blood of patients affected from severe Dengue disease, the hemorrhagic form,118 whereas in Kawasaki disease, substantially lower serum AnxA1 levels were obtained in the patients who present with coronary artery aneurysm, the most severe of this acute and systemic vasculitis.119. This evidence concerns the gene ANXA1 and necrotizing vasculitis.