TARDBP and neurodegenerative disease: In addition to LATE-NC characterized by TDP-43 pathology, Lewy bodies (LB) consisting of the deposition of misfolded α-synuclein (α-syn) have been implicated in a group of neurodegenerative diseases (synucleinopathies) including PD and Lewy body dementia (LBD) [12, 59].