APOE and hypertensive disorder: Familial studies, genome-wide association and epidemiological studies on LOAD cases have identified more than 80 risk genes or loci (e.g., APOE4, TREM2, and ABCA7) and non-genetic risk factors (e.g., brain injury, high blood pressure, high cholesterol, depression or anxiety, heart disease, diabetes, and cancer) [18, 23, 72, 80, 97, 104].