AD is characterized by progressive memory loss and AD neuropathological changes (ADNC) including the accumulation of extracellular beta-amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau proteins (pTau) in patient autopsy brains [60, 96]. This evidence concerns the gene MAPT and Alzheimer disease.