Additional neuropathological signatures of AD brains include neuronal and synaptic loss, microgliosis, astrogliosis, cerebral amyloid angiopathy, white matter rarefaction, granulovacuolar degeneration, α-synuclein (α-syn) proteinopathy, and limbic-predominant age-related TDP-43 encephalopathy (LATE) characterized by phosphorylated TDP-43 inclusions [26, 28, 32, 47, 61, 62, 71, 91]. This evidence concerns the gene TARDBP and Alzheimer disease.