APOE and Alzheimer disease: In contrast, the other six minor alleles of rs429358 (C) encoding for APOE4, rs744373 (G) on BIN1, rs5848 (T) on GRN, rs3851179 (C) on PICALM, rs115550680 (G) on ABCA7 and rs75932628 (T) on TREM2 are associated with an increased risk of developing AD [25, 34, 51, 78, 81, 101, 106].