No difference in polyGR aggregate levels was detected in the hippocampus of AD cases with BIN-rs7444373, GRN-rs5848, PICALM-rs3851179, or TMEM106B-rs3173615 when compared to the negative carriers (Fig. 4c–g), and no rare mutation of ABCA7-rs115550680 minor allele (G) was detected in our cohort. The gene discussed is TMEM106B; the disease is Alzheimer disease.