CASP8 and Alzheimer disease: In AD autopsy brains, Nguyen et al., 2025 showed a subset of polyGR+ aggregates is caused by an interrupted GGGAGA repeat expansion within a SINE/VNTR/Alu (SVA) retrotransposable element in intron 8 of the caspase-8 (CASP8-GGGAGAEXP) [68].