PBLD and neoplasm: Phenazine biosynthesis‐like domain‐containing protein (PBLD) is an isomerase expressed in multiple tissues.[11] Accumulating evidence indicates it plays a tumor‐suppressive role in various cancers.[11, 12] Further studies have demonstrated the association of PBLD with tumorigenesis‐related signaling pathways, including angiogenesis through the VEGF–VEGFR2 signaling pathway, and attenuation of intestinal inflammation via the suppression of NF‐κB‐associated signaling pathways.[13, 14] Our recent studies have revealed a critical role of PBLD in antiviral immunity.