PBLD and viral infectious disease: A similar trend was observed in prior studies on cells infected with vesicular stomatitis virus and bovine ephemeral fever virus, revealing a conserved pattern of PBLD suppression during viral infection.[15] Functional studies have demonstrated that PBLD deficiency significantly enhanced viral infectivity, as evidenced by the increased susceptibility of Pbld‐KO mice to HAdV‐4 infection compared to their WT littermates.