Previous studies have reported that the E3 ligase MARCH2 acts as a negative regulator of MAVS‐ and NF‐κB‐mediated signaling during viral infection.[25, 26] It is negatively correlated with the positive regulatory role of PBLD in MAVS‐ and NF‐κB‐mediated innate immune responses. This evidence concerns the gene MAVS and viral infectious disease.