Consistently, RNA‐seq data indicated that TMPD administration in Pbld+/+ mice increased Tmem173 mRNA expression compared with that in Pbld−/− mice (Figure 7G), suggesting that PBLD deficiency in the TMPD‐induced murine lupus mice model leads to attenuated autoimmune phenotypes. This evidence concerns the gene PBLD and systemic lupus erythematosus.