Our results indicate that TEFB acts as a regulator of PBLD transcription during viral infection, which is consistent with a previous report identifying TEFB as the master regulator of PBLD expression upon rapamycin induction.[24] Furthermore, we demonstrated that viral infection upregulated the E3 ligase MARCH2, which catalyzes K48‐linked ubiquitination and subsequent degradation of the PBLD protein. Here, PBLD is linked to viral infectious disease.