This observation differs from previous reports, indicating that CCDC50 delivers K63‐polyubiquitinated STING and RIG‐I/MDA5 for autophagic degradation during viral infection.[20, 43] These results suggest that CCDC50 recognizes diverse ubiquitin modifications (K48‐, or K63‐linked, and site‐specific) on STING to drive its autophagy‐dependent degradation. This evidence concerns the gene IFIH1 and viral infectious disease.