Consistent with this, downregulation of CCDC50 expression, which enhances STING expression, has been implicated in the pathogenesis of SLE.[20] STING has been shown to be responsible for inducing the TFEB activation.[50] Moreover, TFEB itself can also induce PBLD expression.[24] This suggests a potential positive feedback loop between TFEB and PBLD that may regulate the STING‐mediated immune response. Here, CCDC50 is linked to systemic lupus erythematosus.