This observation differs from previous reports, indicating that CCDC50 delivers K63‐polyubiquitinated STING and RIG‐I/MDA5 for autophagic degradation during viral infection.[20, 43] These results suggest that CCDC50 recognizes diverse ubiquitin modifications (K48‐, or K63‐linked, and site‐specific) on STING to drive its autophagy‐dependent degradation. Here, RIGI is linked to viral infectious disease.