Such abnormalities may disrupt muscle function, leading to sarcomere dysfunction and subsequent muscle weakness.[5,6] NM is genetically determined and follows both autosomal dominant (AD) and recessive inheritance patterns.[7] Mutations in actin alpha 1 (ACTA1) and nebulin are the most common etiological factors associated with NM.[8]. This evidence concerns the gene ACTA1 and Alzheimer disease.