In this study, by WES, 3 novel pathogenic variants were detected in 3 PID patients with elevated IgE including c.2204A > T, p.Asp735Val in the PTPRC gene, c.586T > A, p.Phe196Ile in the UNC119 gene, and c.481C > T, p.Arg161Cys in the IL21R. The gene discussed is UNC119; the disease is pelvic inflammatory disease.