This result showed that the patients in the study did not have typical symptoms of syndromes leading to increased IgE, such as hyper-IgE syndrome (HIES), Netherton syndrome (NS) or Comel-NS, Omenn syndrome (OS), immune dysregulation polyendocrinopathy enteropathy X-linked syndrome (IPEX), and Wiskott-Aldrich syndrome (WAS). Here, IGHE is linked to immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.