This result was also reported in patients with OS syndrome.[16,17] Patients with IPEX syndrome have normal IgA, IgG, and IgM levels[18,19] but increased CD3 + and CD4 + levels.[20,21] In WAS patients, IgA and IgE levels are reported to be increased, while IgG and IgM levels are decreased.[22] However, in a case report of a 10-month-old boy with WAS, his immunologic profile showed elevated levels of IgE and IgA but normal IgG and IgM levels.[23]. This evidence concerns the gene IGHE and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.