This highlights the implications for our understanding of the pathogenesis and clinical management of patients with these complex and challenging forms of PID.[10] Early and accurate diagnosis of the variants associated with each form of PID can lead to effective medical interventions and treatments for patients.[4] Over the past decade, molecular diagnostics, especially next-generation sequencing, have contributed to the accurate diagnosis and elucidation of novel genetic defects associated with elevated IgE levels.[11]. The gene discussed is IGHE; the disease is pelvic inflammatory disease.