EPO and anemia (phenotype): CRP, an acute phase protein, is a common indicator of inflammation in epidemiologic research and standard clinical practice.[27] According to one study, elevated CRP levels were associated with decreased erythropoietin in patients with anemia.[28] Furthermore, Jiawei Li et al pointed out that CRP may be a helpful inflammatory marker for anemia, particularly in anemia of inflammation with diabetic foot ulcer, and they found an L-shaped curve in the association between CRP levels and the risk of anemia.[29]