Furthermore, physical activity can also induce an anti-inflammatory response by facilitating the release of myogenic IL-6, which promotes the secretion of interleukin-10 and interleukin-1 receptor antagonist.[48] Physical activity is the principal modifiable risk factor for obesity, while fat is the largest endocrine organ in the human body, and body fat seems to be the major determinant of inflammation.[49] The indicator commonly employed to identify the presence and severity of excessive fat in adult bodies is BMI, yet BMI underestimates the influence of central obesity on health. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.