While NF-κB has been identified as a significant activator of apoptosis through its interaction with p53 and is negatively regulated by Bcl-2, it has indicated that the administration of M2b macrophages significantly mitigates early myocardial ischemia/reperfusion injury by inhibiting NF-κB signaling.[104]. The gene discussed is BCL2; the disease is myocardial ischemia.