MicroRNAs have been demonstrated to play an important role in the regulation of apoptosis in CHD.[61] Specific miRNAs have been implicated in the pathogenesis of CHD by modulating critical genes and pathways associated with anti-apoptotic mechanisms.[62] Among these, miR-320 has emerged as a particularly important miRNA in CHD, as it regulates cardiac ischemia/reperfusion injury through regulating heat-shock protein 20 (HSP20). Here, HSPB6 is linked to myocardial ischemia.