Nevertheless, despite TNF-α being a crucial activator of extrinsic apoptosis, the use of its antagonist, etanercept, has not yielded the anticipated results in patients with AMI.[105] Additionally, patients with psoriasis have shown benefits from anti-TNF-α treatments.[106] Not all apoptosis-related regulators are suitable candidates for therapeutic intervention, and those identified in cellular or animal studies require further validation through clinical trials. Here, TNF is linked to psoriasis.